query: SELECT ?item WHERE
  {
    ?item wdt:P279 wd:Q8054 .
    ?item wdt:P703 wd:Q15978631 .
    ?item wdt:P352 ?uniprot .
    ?item schema:description ?d .
    FILTER REGEX(?d, "annotated by UniProtKB/TrEMBL") .
    FILTER NOT EXISTS {?gene wdt:P688 ?item}
    FILTER NOT EXISTS {?item wdt:P702 ?gene}
    FILTER NOT EXISTS {?article schema:about ?item}
  }