query: SELECT ?cities ?item  WHERE { 
    VALUES ?citytypes {wd:Q29045219 wd:Q482821 wd:Q16181672 wd:Q4249901 wd:Q29045252}
    ?cities wdt:P31 ?citytypes
    MINUS {?cities wdt:P31/wdt:P279* wd:Q10864048 }
    ?cities wdt:P1082 ?population .
    FILTER (?population > 250000) .
    ?cities wdt:P1313 ?item .
    MINUS { ?item wdt:P576 [] } 
  }